Nanomicelles co-loaded with doxorubicin and salvianolic acid A for breast cancer chemotherapy

Abstract Background Multi-drug delivery system based on polymer carrier is emerging for alleviating dose-limiting toxicities of first-line cytotoxic anticancer drugs, such as doxorubicin (DOX) breast cancer chemotherapy. By co-loading the premium natural antioxidant salvianolic acid A (SAA) through colloidal self-assembly amphiphilic copolymer, we herein developed CPMSD, a complex polymeric micellar to overcome cardiotoxicity associated with DOX. Results Optimal formulation was obtained by DOE study and CPMSD micelles were well constructed using mPEG-PCL entrapment at drug–carrier mass ratio 1:5 DOX–SAA 1:4. Molecular dynamics simulation revealed ratiometrical co-encapsulation SAA into hydrophobic cavity but DOX ball-shaped surface due hydrophilicity. Characterization manifested favorable biopharmaceutical properties, small uniform particle size, fairly high drug loading capacity, good stability controlled release. maintained efficacy action mechanism, which did not be affected co-administering SAA. More point, it great benefit systemic safety cardioprotective effect against oxidative stress injuries in tumor-bearing mice. Conclusions All findings substantiated that would promising multifunctional nanosystem